Coated Sodium Butyrate 50% is a microencapsulated, food-grade dietary supplement ingredient consisting of 50% active sodium butyrate (C₄H₇NaO₂, CAS 156-54-7) — the sodium salt of butyric acid, a naturally occurring short-chain fatty acid (SCFA) — and 50% edible coating matrix (typically hydrogenated vegetable oil, palm stearin, or a lipid–polymer composite). The coating masks the strong rancid-cheese odor of raw butyrate, protects the active from gastric acid, and enables gradual, targeted release through the small intestine into the colon, where butyrate serves as the primary energy source for intestinal epithelial cells.
In the coated form it appears as white to off-white, free-flowing beadlets or granules, essentially odorless, non-hygroscopic, and suitable for hard-shell capsules, tablets, and dry sachet blends.
Mechanism of Action:
Colonocyte fuel: Butyrate supplies ~60–70% of the energy needs of healthy colonocytes; supports mucosal repair, villus integrity, and tight-junction function.
Barrier & inflammation: Acts as a histone deacetylase (HDAC) inhibitor, promoting regulatory T-cell activity and down-regulating NF-κB–driven inflammatory signaling.
Microbiota support: Favors Lactobacillus and Bifidobacterium growth, lowers luminal pH, competes against pathogenic overgrowth.
Post-antibiotic & IBS context: Studied as a supportive nutrient in mild IBS, symptomatic diverticular disease, post-antibiotic recovery, and general gut-barrier maintenance.
Common Finished Formats:
Hard-shell capsules (HPMC or gelatin): 600 mg 50% coated SB → 300 mg active sodium butyrate per cap; typical dose 1 cap/day or 1 cap BID with meals.
Tablets: 800–1400 mg tablet delivering 400–700 mg sodium butyrate; direct-compression or low-heat wet-granulation compatible.
Sachet / functional powder: Blended with inulin, acacia gum, or resistant starch at 30–70% dilution.
Stacks: Frequently paired with probiotics, partially hydrolyzed guar gum, L-glutamine, and zinc carnosine in gut-health formulas.
Storage & Handling:
Store in a cool, dry, sealed container (15–25 °C, RH < 55%). Keep away from strong oxidizers and prolonged heat (>30 °C can soften lipid coat). Shelf life 12–24 months depending on coating system. During manufacturing, avoid high-shear mixing that fractures beads and releases odor; use low-level colloidal silica for flow, minimal magnesium stearate.
