Ivermectin, a macrocyclic lactone derivative, is used in veterinary practice as a heartworm preventative medication and to treat pets infected by parasites.
– For most dogs signs of toxicosis may be seen at doses greater than 2 mg/kg (0.9 mg/lb). Dogs affected by genetic sensitivity can have toxicosis with as little as 0.1 mg/kg (0.04 mg/lb).
– Clinical signs of toxicosis in cats have been reported at doses of 0.3-0.4 mg/kg (0.1 mg/lb).
